Charlie Blackmon produced a first run this season and the Colorado Rockies beat the Oakland A's 5-1 on Wednesday.
Blackmon drove Trevor Story home with a double in the eighth, making the score 3-1.
The last two points were the result of an error by Jesus Luzardo, in ninth.
Blackmon was the National batting champion in 2017.
The Rockies are undefeated in their last four games.
German Marquez (1-1) allowed one run and four hits in six innings, striking out eight batters.
Matt Chapman hit a home run in a losing cause.
Diamondbacks 4 Rangers 7
The Texas Rangers scored five points in the eighth, edging out to a 7-4 victory over the Arizona Diamondbacks.
Joey Gallo tied the score 4-4 with a two-run homer, then Elvis Andrus and Nick Solak added productive singles.
Rangers' Lance Lynn allowed just one hit in six innings, striking out eight batters.
White Sox 4 Indians 0
Luis Robert hit a two-run single in the White Sox's four-run ninth inning and Chicago defeated the Cleveland Indians, 4-0.
Sox hitters 7-9 all provided a hit. Their hitters 1-3 all scored a run. Lead hitter Tim Anderson had a single and a double.
Jose Ramirez hit three of the Indians' six hits, who had posted three wins in a row.
The goals were full when Alex Colome ended the game with Domingo Santana on a roll.
Royals 4 Tigers 5
JaCoby Jones broke the stalemate in the seventh by hitting a solo homerun and the Tigers relievers once again came to the team's aid to allow the Detroit side to defeat the Kansas City Royals 5-4 .
The relief of the Tigers left the trails empty for four innings to allow the team to close a deficit of 4-0.
Jones hit two doubles before securing the victory for the locals. Jonathan Schoop also hit a long ball in the Tigers side.
Bryan Garcia (1-0), one of four relievers in the Detroit roster, collected his first win in the Majors. Joe Jimenez subsequently got his fourth rescue.
Maikel Franco ended the game with two doubles and a single to his record with the Royals.
Cubs 7 Reds 12
Mike Moustakas and Nick Senzel slammed long balls back to the game, Nick Castellanos had a grand slam and the Cincinnati Reds ended a four-game losing streak by beating the Chicago Cubs 12-7.
Sonny Gray (2-0) continued his record allowing six or fewer hits in 35 straight starts. He only allowed Ian Happ to hit a double and struck out 11 batters over his seven innings of work.
As fear surrounding a possible outbreak of COVID-19 cases within their locker room subsided, the Reds were counting on a full starting roster for the first time this season.
Kyle Hendricks (1-1) played only five innings, allowing two runs in the fourth. The Cubs starter left after Eugenio Suárez filled in the goals in the fifth inning.
Brewers 3 Pirates 0
Brandon Woodruff struck out 10 batters and the Milwaukee Brewers beat the Pittsburgh Pirates 3-0.
Woodruff (1-1) pitched for six and a third innings, allowing just one hit.
Ben Gamel and Keston Hiura provided the attack with circuits.
However, things are going from bad to worse for Christian Yelich, National batting champion in 2018 and 2019. After a night of 0 in 5, his average slipped to. 037 (1 in 27).
Rays 4 Braves 7
Freddie Freeman slammed a two-run homerun and hit four hits to lead the Atlanta Braves to a 7-4 win over the Tampa Bay Rays.
Freeman, who contracted COVID-19 before the start of the shortened season and was so ill that he feared for his life, quickly claimed his title as a formidable hitter. He produced three points in the Braves' home opener.
Darren O'Day (1-0) got his first win of the season.
The Braves stopped the Rays, who were on a four-game winning streak.
The Rays had managed to take a 4-2 lead in the sixth inning, thanks to a single from Kevin Kiermaier and a two-run single from Hunter Renfroe. The relievers were unable to hold the fort after a solid outing from Charlie Morton, however.
Yankees 9 Orioles 3
DJ LeMahieu, Aaron Judge and Aaron Hicks produced two runs apiece, helping the New York Yankees to dominate the Baltimore Orioles, 9-3.
LeMahieu went to a triple from the carousel, while Judge scored points.
Giancarlo Stanton produced a fifth point in four games, going from a simple opportune.
Gerrit Cole (2-0) gave up three runs in six and two-thirds innings, striking out seven batters.
Red Sox 6 Mets 5
Christian Vazquez produced three runs and the Boston Red Sox ended a four-game losing streak, winning 6-5 over the New York Mets.
His solo homerun tied 3-3, then his two-run single gave the visitors a 6-3 cushion.
Brandon Workman allowed two walks, two singles and one run, still getting the save.
Cardinals 0 Twins 3
Rich Hill did not allow a run in five innings in his debut with the Twins and the Minnesota roster shut out the St. Louis Cardinals 3-0.
Eddie Rosario hit a solo homerun, while Nelson Cruz hit a one-run double. Alex Avila, a newcomer to the Twins, also helped his team win by hitting a single point.
Taylor Rogers was perfect in the ninth to collect his first save and the Twins swept the two-game series to 4-1.
Daniel Ponce de Leon (0-1) struck out eight batters in three and two-thirds innings. However, he conceded two hits, three walks and the three runs scored by the Twins. He was replacing Miles Mikolas, who will be on the sidelines for the remainder of the season with forearm surgery.